US Patent Number
The present disclosure relates to the synthesis of non-natural analogs of S-adenosyl-L-methionine (SAM) and/or of Se-adenosyl- L-methionine (SeAM) by reacting a methionine analog and adenosine triphosphate (ATP) in the presence of at least one methionine adenosyltransferase (MAT), and to use thereof with downstream SAM and/or SeAM utilizing enzymes.
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University of Kentucky Research Foundation, Lexington, KY (US)
Thorson, Jon S.; Huber, Tyler; Zhang, Jianjun; and Singh, Shanteri, "Synthesis of Non-Natural Cofactor Analogs of S-adenosyl-L-methionine Using Methionine Adenosyltransferase" (2018). Pharmaceutical Sciences Faculty Patents. 171.