US Patent Number
9,895,324
Publication Date
2-20-2018
Abstract
Halogenated diarylacetylenes, e.g., diarylacetylenes having at least one halo substituent in one aryl ring and an amine in the opposing aryl ring, can inhibit the proliferation of LSI 74T colon cancer cells through the inhibition of c-myc and induction of the cyclin-dependent kinase inhibitor-I (i.e., p21(Wifl/Cipl)). Such compounds are useful as antineoplastic agents.
Assignees
University of Kentucky Research Foundation, Lexington, KY (US)
Application Number
14/668,865
Filing Date
03/25/2015
Recommended Citation
Sviripa, Vitaliy M.; Zhang, Wen; Liu, Chunming; and Watt, David S., "Halogenated Diarylacetylenes and Methods of Treating Cancer" (2018). Pharmaceutical Sciences Faculty Patents. 173.
https://uknowledge.uky.edu/ps_patents/173
