Synthesis of Non-Natural Cofactor Analogs of S-adenosyl-L-methionine Using Methionine Adenosyltransferase

Authors

Jon S. Thorson, University of KentuckyFollow
Tyler Huber, University of KentuckyFollow
Jianjun Zhang, University of KentuckyFollow
Shanteri Singh, University of KentuckyFollow

US Patent Number

9,879,043

Publication Date

1-30-2018

Abstract

The present disclosure relates to the synthesis of non-natural analogs of S-adenosyl-L-methionine (SAM) and/or of Se-adenosyl- L-methionine (SeAM) by reacting a methionine analog and adenosine triphosphate (ATP) in the presence of at least one methionine adenosyltransferase (MAT), and to use thereof with downstream SAM and/or SeAM utilizing enzymes.

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Assignees

University of Kentucky Research Foundation, Lexington, KY (US)

Application Number

14/298,874

Filing Date

06/06/2014

Recommended Citation

Thorson, Jon S.; Huber, Tyler; Zhang, Jianjun; and Singh, Shanteri, "Synthesis of Non-Natural Cofactor Analogs of S-adenosyl-L-methionine Using Methionine Adenosyltransferase" (2018). Pharmaceutical Sciences Faculty Patents. 171.
https://uknowledge.uky.edu/ps_patents/171