Archived
This content is available here strictly for research, reference, and/or recordkeeping and as such it may not be fully accessible. If you work or study at University of Kentucky and would like to request an accessible version, please use the SensusAccess Document Converter.
US Patent Number
9,879,240
Publication Date
1-30-2018
Abstract
The Bacterial cocaine esterase (CocE) mutants disclosed herein each have enhanced catalytic efficiency for ( -)cocaine, as compared to CocE mutants in the prior art, including CocE mutant E172-173. The presently-disclosed subject matter further includes a pharmaceutical composition including a mutant of bacterial cocaine hydrolase, as described herein, and a suitable pharmaceutical carrier. The presently-disclosed subject matter further includes a method of treating a cocaine-induced condition comprising administering to an individual an effective amount of a mutant of bacterial cocaine hydrolase variant, as disclosed herein, to accelerate cocaine metabolism and produce biologically inactive metabolites.
Assignees
University of Kentucky Research Foundation, Lexington, KY (US)
Application Number
14/924,181
Filing Date
10/27/2015
Recommended Citation
Zhan, Chang-Guo; Zheng, Fang; and Fang, Lei, "High Activity Mutants of Cocaine Esterase for Cocaine Hydrolysis" (2018). Pharmaceutical Sciences Faculty Patents. 172.
https://uknowledge.uky.edu/ps_patents/172
