This collection was named as Graduate Center for Toxicology Faculty Publications before Jan. 1, 2015.

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Submissions from 2020

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Resolving Metabolic Heterogeneity in Experimental Models of the Tumor Microenvironment from a Stable Isotope Resolved Metabolomics Perspective, Teresa W-M Fan, Richard M. Higashi, Yelena Chernayavskaya, and Andrew N. Lane

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Spermine Synthase and MYC Cooperate to Maintain Colorectal Cancer Cell Survival by Repressing Bim Expression, Yubin Guo, Qing Ye, Pan Deng, Yanan Cao, Daheng He, Zhaohe Zhou, Chi Wang, Yekaterina Y. Zaytseva, Charles E. Schwartz, Eun Young Lee, B. Mark Evers, Andrew J. Morris, Side Liu, and Qing-Bai She

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A Brief Educational Intervention Enhances Basic Cancer Literacy Among Kentucky Middle and High School Students, Lauren Hudson, Kerrigan M. Samons, Haley E. Dicken, Chris Prichard, L. Todd Weiss, Jean Edward, Robin C. Vanderpool, and Nathan L. Vanderford

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Rho GTPases: Big Players in Breast Cancer Initiation, Metastasis and Therapeutic Responses, Brock Humphries, Zhishan Wang, and Chengfeng Yang

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SOD2 Deficiency in Cardiomyocytes Defines Defective Mitochondrial Bioenergetics as a Cause of Lethal Dilated Cardiomyopathy, Sudha Sharma, Susmita Bhattarai, Hosne Ara, Grace Sun, Daret K. St. Clair, Md Shenuarin Bhuiyan, Christopher Kevil, Megan N. Watts, Paari Dominic, Takahiko Shimizu, Kevin J. McCarthy, Hong Sun, Manikandan Panchatcharam, and Sumitra Miriyala

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IGF-1R Inhibition Induces MEK Phosphorylation to Promote Survival in Colon Carcinomas, Qing Wang, Yan Zhang, Jiang Zhu, Honggang Zheng, Shuntai Chen, Li Chen, and Hsin-Sheng Yang

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Develop a High-Throughput Screening Method to Identify C-P4H1 (Collagen Prolyl 4-Hydroxylase 1) Inhibitors from FDA-Approved Chemicals, Shike Wang, Kuo-Hao Lee, Nathália Victoria Araujo, Chang-Guo Zhan, Vivek M. Rangnekar, and Ren Xu

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HDAC6 Mediates Macrophage iNOS Expression and Excessive Nitric Oxide Production in the Blood During Endotoxemia, Yan Wang, Ke Wang, and Jian Fu

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Neutrophil: A New Player in Metastatic Cancers, Mengyue Wu, Mutian Ma, Zhenya Tan, Hong Zheng, and Xia Liu

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Upregulation of CPT1A Is Essential for the Tumor-Promoting Effect of Adipocytes in Colon Cancer, Xiaopeng Xiong, Yang-An Wen, Rachelle Fairchild, Yekaterina Y. Zaytseva, Heidi L. Weiss, B. Mark Evers, and Tianyan Gao

Submissions from 2019

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The Benefits of Lasix for Exercise-Induced Pulmonary Hemorrhage: 50 Years of Science and Clinical Experience, Kimberly Brewer, Clara Fenger, and Thomas Tobin

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Protective Effects of Novel Derivatives of Vitamin D3 and Lumisterol Against UVB-Induced Damage in Human Keratinocytes Involve Activation of Nrf2 and p53 Defense Mechanisms, Anyamanee Chaiprasongsuk, Zorica Janjetovic, Tae-Kang Kim, Stuart G. Jarrett, John A. D'Orazio, Michael F. Holick, Edith K. Y. Tang, Robert C. Tuckey, Uraiwan Panich, Wei Li, and Andrzej T. Slominski

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MicroRNA Regulation of Epigenetic Modifiers in Breast Cancer, Brock Humphries, Zhishan Wang, and Chengfeng Yang

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Circular RNA circNOL10 Inhibits Lung Cancer Development by Promoting SCLM1-Mediated Transcriptional Regulation of the Humanin Polypeptide Family, Aruo Nan, Lijian Chen, Nan Zhang, Yangyang Jia, Xin Li, Hanyu Zhou, Yihui Ling, Zhishan Wang, Chengfeng Yang, Sijin Liu, and Yiguo Jiang

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A Case-Control Study of Trace-Element Status and Lung Cancer in Appalachian Kentucky, Jason M. Unrine, Stacey A. Slone, Wayne T. Sanderson, Nancy E. Johnson, Eric B. Durbin, Shristi Shrestha, Ellen J. Hahn, Fran Feltner, Bin Huang, W. Jay Christian, Isabel Mellon, David K. Orren, and Susanne M. Arnold

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Extracellular Vesicle-Mediated Macrophage Activation: An Insight Into the Mechanism of Thioredoxin-Mediated Immune Activation, Chontida Yarana, Hannah Thompson, Luksana Chaiswing, D. Allan Butterfield, Heidi L. Weiss, Subbarao Bondada, Sara S. Alhakeem, Suriyan Sukati, and Daret K. St. Clair

Submissions from 2018

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GRP78 Is a Targetable Receptor on Cancer and Stromal Cells, Nathalia Araujo, Nikhil Hebbar, and Vivek M. Rangnekar

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Acute Loss of Iron-Sulfur Clusters Results in Metabolic Reprogramming and Generation of Lipid Droplets in Mammalian Cells, Daniel R. Crooks, Nunziata Maio, Andrew N. Lane, Michal Jarnik, Richard M. Higashi, Ronald G. Haller, Ye Yang, Teresa Whei-Mei Fan, W. Marston Linehan, and Tracey A. Rouault

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Stable Isotope-Resolved Metabolomics Shows Metabolic Resistance to Anti-Cancer Selenite in 3D Spheroids Versus 2D Cell Cultures, Teresa W. -M. Fan, Salim S. El-Amouri, Jessica K. A. Macedo, Qing Jun Wang, Huan Song, Teresa Cassel, and Andrew N. Lane

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Lasix Lessons Learned: Science Confirms What American Horsemen Knew 50 Years Ago, Clara Fenger, Steve Selway, and Thomas Tobin

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Trace-Level Identifications Are Not Positives: The Scientifically Correct and Public Relations-Appropriate Approach to Medication Regulation, Clara Fenger and Thomas Tobin

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Hitting the Threshold of Common Sense: The Time for Screening Limits to Guard Against Environmental Transfer Is Now, Clara Fenger, Thomas Tobin, Maria Catignani, and Theodore Shults

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Beta-Catenin Cleavage Enhances Transcriptional Activation, Tatiana Goretsky, Emily M. Bradford, Qing Ye, Olivia F. Lamping, Tomas Vanagunas, Mary Pat Moyer, Patrick C. Keller, Preetika Sinh, Josep M. Llovet, Tianyan Gao, Qing-Bai She, Linheng Li, and Terrence A. Barrett

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ALS Mutations of FUS Suppress Protein Translation and Disrupt the Regulation of Nonsense-Mediated Decay, Marisa Kamelgarn, Jing Chen, Lisha Kuang, Huan Jin, Edward J. Kasarskis, and Haining Zhu

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Doxorubicin-Induced Elevated Oxidative Stress and Neurochemical Alterations in Brain and Cognitive Decline: Protection by MESNA and Insights into Mechanisms of Chemotherapy-Induced Cognitive Impairment ("Chemobrain"), Jeriel T. R. Keeney, Xiaojia Ren, Govind Warrier, Teresa Noel, David K. Powell, Jennifer M. Brelsfoard, Rukhsana Sultana, Kathryn E. Saatman, Daret K. St. Clair, and D. Allan Butterfield