US Patent Number
6890752
Publication Date
5-10-2005
Abstract
Novel synthases and the corresponding nucleic acids encoding such synthases are disclosed herein. Such synthases possess an active site pocket that includes key amino acid residues that are modified to generate desired terpenoid reaction intermediates and products. Synthase modifications are designed based on, e.g., the three-dimensional coordinates of tobacco 5-epi-aristolochene synthase. with or without a substrate bound in the active site.
Assignees
The University of Kentucky Research Foundatino, Lexington, KY (US), The Salk Institute for Biological Studies, San Diego, CA (US)
Application Number
09/893,820
Filing Date
06/28/2001
Recommended Citation
Chappell, Joseph; Manna, Kathleen R.; Noel, Joseph P.; and Starks, Courtney M., "Synthases" (2005). Pharmaceutical Sciences Faculty Patents. 69.
https://uknowledge.uky.edu/ps_patents/69
