US Patent Number
8846887
Publication Date
9-30-2014
Abstract
Butyrylcholinesterase (BChE) polypeptide variants of the presently-disclosed subject matter have enhanced catalytic efficiency for (−)-cocaine, as compared to wild-type BChE. Pharmaceutical compositions of the presently-disclosed subject matter include a BChE polypeptide variant having an enhanced catalytic efficiency for (−)-cocaine. A method of the presently-disclosed subject matter for treating a cocaine-induced condition includes administering to an individual an effective amount of a BChE polypeptide variant, as disclosed herein, to lower blood cocaine concentration.
Assignees
University of Kentucky Research Foundation, Lexington, KY (US)
Application Number
13/479,899
Filing Date
05/24/2012
Recommended Citation
Zhan, Chang-Guo; Zheng, Fang; and Yang, Wenchao, "High Activity Mutants of Butyrylcholinesterase for Cocaine Hydrolysis" (2014). Pharmaceutical Sciences Faculty Patents. 22.
https://uknowledge.uky.edu/ps_patents/22
