US Patent Number
8546415
Publication Date
10-1-2013
Abstract
N-n-Alkylation of nicotine converts nicotine from an agonist into an antagonist specifically for neuronal nicotinic acetylcholine receptor subtypes mediating nicotine-evoked dopamine release. Conformationally restricted analogs exhibit both high affinity and selectivity at this site, and are able to access the brain due to their ability to act as substrates for the blood-brain barrier choline transporter.
Assignees
University of Kentucky Research Foundation, Lexington, KY (US)
Application Number
12/714,219
Filing Date
02/26/2010
Recommended Citation
Crooks, Peter A.; Dwoskin, Linda P.; Ayers, Joshua; Grinevich, Vladimir; and Sumithran, Sangeetha, "Bis-Pyridino Containing Compounds for the Use in the Treatment of CNS Pathologies" (2013). Pharmaceutical Sciences Faculty Patents. 16.
https://uknowledge.uky.edu/ps_patents/16
