US Patent Number
5019370
Publication Date
5-28-1991
Abstract
A biodegradable, low biological toxicity, particulate radiographic contrast medium comprises biodegradable polymeric spheres of average molecular weight average diameter about 10-1,000 nm or about 0.01-1.0 micron carrying in at least radiographic contrasting amount of a radiographically opaque element.
A method of obtaining a tomographic image of the body portion of a subject comprises administering to the subject a radiographically-detectable amount of the biodegradable, low-toxicity radiographic medium of claim 1; allowing for the spheres to be taken-up by the body portion; and X-raying an area comprising the body portion.
A method of improving the contrast of a tomographic image of a body portion of a subject comprises administering to the subject a radiographically-detectable amount of the biodegradable, low-toxicity radiographic medium of claim 1; allowing for the spheres to be selectively taken-up by the body portion; and X-raying an area comprising the body portion.
Assignees
University of Kentucky Research Foundation, Lexington, Ky.
Application Number
377,396
Filing Date
07/10/1989
Recommended Citation
Jay, Michael J. and Ryo, Yun, "Biodegradable, Low Biological Toxicity Radiographic Contrast Medium and Method of X-Ray Imaging" (1991). Pharmaceutical Sciences Faculty Patents. 147.
https://uknowledge.uky.edu/ps_patents/147
