US Patent Number
5032402
Publication Date
7-16-1991
Abstract
The novel compound, 3-hydroxy-N-methylpyrrolidone, is effective as a transdermal enhancer for the absorption of drugs through the skin of humans and animals. The 3-hydroxy-N-methylpyrrolidone is prepared from delta-butyrolactone which is converted to methyl 2,4-dibromobutyrate, this intermediate is reacted with methylamine to form N-methyl-2,4-dibromobutyramide, this intermediate is converted to 3-bromo-N-methyl-2-pyrrolidone by ring closure, and the 3-bromo-N-methyl-2-pyrrolidone is reacted with an alkaline earth metal carbonate or alkaline metal carbonate to form 3-hydroxy-N-methyl-2-pyrrolidone.
Assignees
University of Kentucky Research Foundation, Lexington, Ky.
Application Number
554,501
Filing Date
07/19/1990
Recommended Citation
Digenis, George A.; Doll, Walter J.; and Hawi, Amale, "3-Hydroxy-N-Methylpyrrolidone and Use as Transdermal Enhancer" (1991). Pharmaceutical Sciences Faculty Patents. 136.
https://uknowledge.uky.edu/ps_patents/136
