Polymer Bound Elastase Inhibitors

Authors

George A. Digenis, University of KentuckyFollow
Bushra J. Agha, University of Kentucky
William R. Banks
Frantisek Rypacek

US Patent Number

5162307

Publication Date

11-10-1992

Abstract

Pharmaceutical compositions and methods of inhibiting the enzyme elastase and increasing the biological half-life and/or potency in terms of inhibitory activity of the enzyme elastase of peptide compounds is achieved by use of a polymer of the formula P--(L--R)_q wherein P is a polymer containing at least one unit of the formula (A_n B_n) wherein A_n B_n is substantially nonbiodegradable, and has an average molecular weight of about 1,000 to 5,000 daltons, L is a covalent bond or a linker group and R is a peptide.

Assignees

The Board of Trustees of the University of Kentucky, Lexington, Ky., Czechoslovak Academy of Sciences, Czechoslovakia

Application Number

857,119

Filing Date

03/25/1992

Recommended Citation

Digenis, George A.; Agha, Bushra J.; Banks, William R.; and Rypacek, Frantisek, "Polymer Bound Elastase Inhibitors" (1992). Pharmaceutical Sciences Faculty Patents. 135.
https://uknowledge.uky.edu/ps_patents/135