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US Patent Number
5162307
Publication Date
11-10-1992
Abstract
Pharmaceutical compositions and methods of inhibiting the enzyme elastase and increasing the biological half-life and/or potency in terms of inhibitory activity of the enzyme elastase of peptide compounds is achieved by use of a polymer of the formula P--(L--R)q wherein P is a polymer containing at least one unit of the formula (An Bn) wherein An Bn is substantially nonbiodegradable, and has an average molecular weight of about 1,000 to 5,000 daltons, L is a covalent bond or a linker group and R is a peptide.
Assignees
The Board of Trustees of the University of Kentucky, Lexington, Ky., Czechoslovak Academy of Sciences, Czechoslovakia
Application Number
857,119
Filing Date
03/25/1992
Recommended Citation
Digenis, George A.; Agha, Bushra J.; Banks, William R.; and Rypacek, Frantisek, "Polymer Bound Elastase Inhibitors" (1992). Pharmaceutical Sciences Faculty Patents. 135.
https://uknowledge.uky.edu/ps_patents/135
