US Patent Number
5160745
Publication Date
11-3-1992
Abstract
A method for preparing biodegradable microspheres having a three-dimensional network in which biologically active macromolecular agents are physically entrapped therein. The microsphere is able to degrade and release the macromolecular agent at a controlled rate. The method involves emulsifying a vinyl derivative of a biodegradable hydrophilic polymer, a water-soluble monovinyl monomer and a biologically active macromolecule in water, and copolymerizing the biodegradable hydrophilic polymer and the water-soluble monovinyl monomer such that the biologically active macromolecule is entrapped therein.
Assignees
University of Kentucky Research Foundation, Lexington, Ky.
Application Number
463,008
Filing Date
01/09/1990
Recommended Citation
DeLuca, Patrick P. and Rypacek, Frantisek, "Biodegradable Microspheres as a Carrier for Macromolecules" (1992). Pharmaceutical Sciences Faculty Patents. 132.
https://uknowledge.uky.edu/ps_patents/132
