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Submissions from 2016

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Unexpected Reaction Pathway for Butyrylcholinesterase-Catalyzed Inactivation of "Hunger Hormone" Ghrelin, Jianzhuang Yao, Yaxia Yuan, Fang Zheng, and Chang-Guo Zhan

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Physicochemical Properties of Engineered Nanomaterials that Influence Their Nervous System Distribution and Effects, Robert A. Yokel

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Purin-6-One Derivatives as Phosphodiesterase-2 Inhibitors, Wei Yuan, Xin-Yun Zhao, Xi Chen, and Chang-Guo Zhan

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Role of Histidine 547 of Human Dopamine Transporter in Molecular Interaction with HIV-1 Tat and Dopamine Uptake, Yaxia Yuan, Pamela M. Quizon, Wei-Lun Sun, Jianzhuang Yao, Jun Zhu, and Chang-Guo Zhan

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Extracorporeal Delivery of a Therapeutic Enzyme, Chun Zhang, Jun Pu, Xiaolan Yang, Tao Feng, Fang Liu, Deqiang Wang, Xiaolei Hu, Ang Gao, Hongbo Liu, Chang-Guo Zhan, and Fei Liao

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An Arginine Finger Regulates the Sequential Action of Asymmetrical Hexameric ATPase in the Double-Stranded DNA Translocation Motor, Zhengyi Zhao, Gian Marco De-Donatis, Chad T. Schwartz, Huaming Fang, Jingyuan Li, and Peixuan Guo

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Reply to Curry and Coombs: Benzoic Acid is Formed Predominantly from the Benzoyl Ester Hydrolysis in the Presence of Cocaine Hydrolase, Fang Zheng and Chang-Guo Zhan

Submissions from 2015

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The Biosynthesis of Capuramycin-type Antibiotics: Identification of the A-102395 Biosynthetic Gene Cluster, Mechanism of Self-Resistence, and Formation of Uridine-5'-Carboxamide, Wenlong Cai, Anwesha Goswami, Zhaoyong Yang, Xiaodong Liu, Keith D. Green, Sandra Barnard-Britson, Satoshi Baba, Masanori Funabashi, Koichi Nonaka, Manjula Sunkara, Andrew J. Morris, Anatol P. Spork, Christian Ducho, Sylvie Garneau-Tsodikova, Jon S. Thorson, and Steven Van Lanen

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FRET Detection of Lymphocyte Function-Associated Antigen-1 Conformational Extension, Alexandre Chigaev, Yelena Smagley, Mark K. Haynes, Oleg Ursu, Cristian G. Bologa, Liliana Halip, Tudor Oprea, Anna Waller, Mark B. Carter, Yinan Zhang, Wei Wang, Tione Buranda, and Larry A. Sklar

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Regression of Gastric Cancer by Systemic Injection of RNA Nanoparticles Carrying Both Ligand and siRNA, Daxiang Cui, Chunlei Zhang, Bing Liu, Yi Shu, Tong Du, Dan Shu, Kan Wang, Fangping Dai, Yanlei Liu, Chao Li, Fei Pan, Yuming Yang, Jian Ni, Hui Li, Beate Brand-Saberi, and Peixuan Guo

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Alternating Magnetic Field-Induced Hyperthermia Increases Iron Oxide Nanoparticle Cell Association/Uptake and Flux in Blood-Brain Barrier Models, Mo Dan, Younsoo Bae, Thomas A. Pittman, and Robert A. Yokel

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Derivation of an Analytical Solution to a Reaction-Diffusion Model for Autocatalytic Degradation and Erosion in Polymer Microspheres, Ashlee N. Ford Versypt, Paul D. Arendt, Daniel W. Pack, and Richard D. Braatz

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Pharmacologically Distinct Nicotinic Acetylcholine Receptors Drive Efferent-Mediated Excitation in Calyx-Bearing Vestibular Afferents, J. Chris Holt, Kevin Kewin, Paivi M. Jordan, Peter Cameron, Marcin Klapczynski, J. Michael McIntosh, Peter A. Crooks, Linda P. Dwoskin, and Anna Lysakowski

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Drug Synergy Drives Conserved Pathways to Increase Fission Yeast Lifespan, Xinhe Huang, Markos Leggas, and Robert C. Dickson

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An in Vitro Assessment of Liposomal Topotecan Simulating Metronomic Chemotherapy in Combination with Radiation in Tumor-Endothelial Spheroids, Amar Jyoti, Kyle Daniel Fugit, Pallavi Sethi, Ronald C. McGarry, Bradley D. Anderson, and Meenakshi Upreti

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RNA Nanoparticle as a Vector for Targeted siRNA Delivery into Glioblastoma Mouse Model, Tae Jin Lee, Farzin Haque, Dan Shu, Ji Young Yoo, Hui Li, Robert A. Yokel, Craig Horbinski, Tae Hyong Kim, Sung-Hak Kim, Chang-Hyuk Kwon, Ichiro Nakano, Balveen Kaur, Peixuan Guo, and Carlo M. Croce

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Inhibition of Aminoglycoside Acetyltransferase Resistance Enzymes by Metal Salts, Yijia Li, Keith D. Green, Brooke R. Johnson, and Sylvie Garneau-Tsodikova

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Pharmacology: The Pharmacodynamics of Nutrients and Nutrient Interactions in Biological Functions, M. Hasan Mohajeri, Gunter P. Eckert, James R. Pauly, and Christopher M. Butt

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A Combination Approach to Treating Fungal Infections, Sanjib K. Shrestha, Marina Y. Fosso, and Sylvie Garneau-Tsodikova

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Amphiphilic Tobramycin Analogues as Antibacterial and Antifungal Agents, Sanjib K. Shrestha, Marina Y. Fosso, Keith D. Green, and Sylvie Garneau-Tsodikova

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New Approach to Develop Ultra-High Inhibitory Drug Using the Power Function of the Stoichiometry of the Targeted Nanomachine or Biocomplex, Dan Shu, Fengmei Pi, Chi Wang, Peng Zhang, and Peixuan Guo

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Crystal Structure of O-Methyltransferase CalO6 from the Calicheamicin Biosynthetic Pathway: A Case of Challenging Structure Determination at Low Resolution, Oleg V. Tsodikov, Caixia Hou, Christopher T. Walsh, and Sylvie Garneau-Tsodikova

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Chemically Related 4,5-Linked Aminoglycoside Antibiotics Drive Subunit Rotation in Opposite Directions, Michael R. Wasserman, Arto Pulk, Zhou Zhou, Roger B. Altman, John C. Zinder, Keith D. Green, Sylvie Garneau-Tsodikova, Jamie H. Doudna Cate, and Scott C. Blanchard

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Influence of Linker Length and Composition on Enzymatic Activity and Ribosomal Binding of Neomycin Dimers, Derrick Watkins, Sunil Kumar, Keith D. Green, Dev P. Arya, and Sylvie Garneau-Tsodikova

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Factors Affecting the Pharmacokinetics and Pharmacodynamics of PEGylated Liposomal Irinotecan (IHL-305) in Patients with Advanced Solid Tumors, Huali Wu, Jeffrey R. Infante, Vicki L. Keedy, Suzanne F. Jones, Emily Chan, Johanna C. Bendell, Wooin Lee, Whitney P. Kirschbrown, Beth A. Zamboni, Satoshi Ikeda, Hiroshi Kodaira, Mace L. Rothenberg, Howard A. Burris, and William C. Zamboni