Author ORCID Identifier
Date Available
5-15-2025
Year of Publication
2023
Degree Name
Master of Science (MS)
Document Type
Master's Thesis
College
Pharmacy
Department/School/Program
Pharmaceutical Sciences
First Advisor
Dr. R. Kip Guy
Abstract
Over the last century, advancements in medicine have been made to improve cancer patients' outcomes. The discovery of new druggable targets is essential to achieving this goal. Defective in Cullin Neddylation 1 is a proven oncogenetic driver that may lead to better clinical outcomes when targeted. In efforts to further improve a series of novel small molecular inhibitors of the DCN1 and UBE2M protein-protein interaction, the Guy lab has designed and synthesized 26 new compounds. These compounds were designed to specifically target the UBE2M N-Acetyl sub-pocket on DCN1 that was not occupied by compounds previously described in the literature.
Digital Object Identifier (DOI)
https://doi.org/10.13023/etd.2023.247
Funding Information
This study was supported by the National Institutes of Health R01CA247365.
Recommended Citation
Moseley, Tucker J., "Design and Synthesis of Small Molecular Inhibitors of DCN1-UBE2M Interaction" (2023). Theses and Dissertations--Pharmacy. 153.
https://uknowledge.uky.edu/pharmacy_etds/153
