Author ORCID Identifier
Date Available
4-29-2020
Year of Publication
2020
Degree Name
Master of Science (MS)
Document Type
Master's Thesis
College
Pharmacy
Department/School/Program
Pharmaceutical Sciences
First Advisor
Dr. David Burgess
Abstract
Pseudomonas aeruginosa causes severe healthcare-associated infections. Forty-eight extensively drug-resistant (XDR)-P. aeruginosa isolates were selected from 287 isolates collected for evaluation based on clinical susceptibility data. In vitro activity of commonly utilized antimicrobials (i.e. antipseudomonal beta-lactams, aminoglycosides, fluoroquinolones, and polymyxins) plus ceftolozane-tazobactam, ceftazidime-avibactam, and aztreonam-avibactam against XDR-P. aeruginosa were determined. The mechanism of resistance profile was determined through phenotypic expression analysis. Overall, polymyxin B and colistin were 100% susceptible. Apart from the polymyxins, ceftolozane-tazobactam had the highest susceptibility (94%) followed by ceftazidime-avibactam (90%) and amikacin (83%). Ceftolozane-tazobactam activity was not significantly different from ceftazidime-avibactam (p=0.6831). Only 40% of isolates were susceptible to aztreonam-avibactam. All other agents demonstrated P. aeruginosa at our institution, in vitro analysis proposes superiority of ceftolozane-tazobactam; however, until further in vitro and in vivo validation both agents are reasonable options.
Digital Object Identifier (DOI)
https://doi.org/10.13023/etd.2020.237
Recommended Citation
Gallagher, Chanah, "EXTENSIVELY DRUG-RESISTANT PSEUDOMONAS AERUGINOSA IN VITRO SUSCEPTIBILITY AND MECHANISMS OF RESISTANCE" (2020). Theses and Dissertations--Pharmacy. 115.
https://uknowledge.uky.edu/pharmacy_etds/115
Included in
Bacteria Commons, Infectious Disease Commons, Pharmacy and Pharmaceutical Sciences Commons
