Date Available
5-20-2021
Year of Publication
2020
Document Type
Master's Thesis
Degree Name
Master of Science (MS)
College
Pharmacy
Department/School/Program
Pharmaceutical Sciences
Advisor
Dr. Patricia Freeman
Abstract
Objectives: The long-term risks associated with the use of short-term prescription opioids in opioid naïve adolescents in not well characterized. The purpose of this study was to explore the potential association between the days’ supply of the initial prescription opioid exposure and the rates of diagnosed OUD in the subsequent 3-year period. Methods: We conducted a retrospective cohort study using a nationwide database of commercially-insured adolescents aged 12-17 at the time of the index opioid fill. A multivariable Cox Proportional Hazard regression model was developed to analyze the association of interest while accounting for known risk factors for the development of OUD. Results: Results of the Cox Proportional Hazard analysis showed no significant differences in the risks of future OUD diagnosis between any of the days’ supply groups. Conclusions: In this commercially-insured, opioid naïve adolescent population, there was no significant association between the days’ supply of the initial opioid prescription the rate of OUD diagnosis in the subsequent 3-year period.
Digital Object Identifier (DOI)
https://doi.org/10.13023/etd.2020.210
Funding Information
Access to the study dataset between July 2019 and May 2020 was supported by the National Institute on Drug Abuse grant R01 DA039928.
Recommended Citation
Lindahl, Eric, "Relationship Between Initial Prescription Opioid Exposure Length and Future Opioid Use Disorder Diagnosis in Opioid Naive Adolescents" (2020). Theses and Dissertations--Pharmacy. 112.
https://uknowledge.uky.edu/pharmacy_etds/112
Included in
Pharmacy Administration, Policy and Regulation Commons, Substance Abuse and Addiction Commons
