Abstract
Background
Metabolic syndrome (MetS) is an important etiologic and prognostic factor for cancer, but few studies have assessed hospitalization outcomes among patients with both conditions.
Methods
Data was obtained from the Healthcare Cost and Utilization project Nationwide Inpatient Sample (HCUP-NIS). Study variables were assessed using ICD-9 codes on adults aged 40 years and over admitted to a US hospital between 2007 and 2011 with primary diagnosis of either breast, colorectal, or prostate cancer. We examined in-hospital mortality, post-surgical complications, and discharge disposition among cancer patients with MetS and compared with non-MetS patients.
Results
Hospitalized breast (OR: 0.31, 95% CI: 0.20–0.46), colorectal (OR: 0.41, 95% CI: 0.35–0.49), and prostate (OR: 0.28, 95% CI: 0.16–0.49) cancer patients with MetS had significantly reduced odds of in-hospital mortality. The odds of post-surgical complications among breast (OR: 1.20, 95% CI: 1.03–1.39) and prostate (OR: 1.22, 95% CI: 1.09–1.37) cancer patients with MetS were higher, but lower by 7% among colorectal cancer patients with MetS. Additionally, breast (OR: 1.21, 95% CI: 1.11–1.32) and colorectal (OR: 1.06, 95% CI: 1.01–1.11) cancer patients with MetS had significantly higher odds for discharge to a skilled nursing facility compared with those without MetS, but this was not statistically significant among prostate cancer patients.
Conclusions
Adverse health outcomes were significantly higher among hospitalized patients with a primary diagnosis of cancer and MetS. Future studies are needed to identify clinical strategies for detecting and managing patients with MetS to reduce the likelihood of poor inpatient outcomes.
Document Type
Article
Publication Date
3-2018
Digital Object Identifier (DOI)
https://doi.org/10.1007/s11695-017-2900-6
Funding Information
This study was funded by grant K01TW010271 from the National Institutes of Health.
Repository Citation
Akinyemiju, Tomi; Sakhuja, Swati; and Vin-Raviv, Neomi, "In-Hospital Mortality and Post-Surgical Complications Among Cancer Patients with Metabolic Syndrome" (2018). Epidemiology and Environmental Health Faculty Publications. 53.
https://uknowledge.uky.edu/epidemiology_facpub/53
Included in
Biochemical Phenomena, Metabolism, and Nutrition Commons, Epidemiology Commons, Oncology Commons, Surgery Commons
Notes/Citation Information
Published in Obesity Surgery, v. 28, issue 3, p. 683-692.
© Springer Science+Business Media, LLC 2017
The copyright holder has granted the permission for posting the article here.
This is a post-peer-review, pre-copyedit version of an article published in Obesity Surgery. The final authenticated version is available online at: https://doi.org/10.1007/s11695-017-2900-6.