Abstract
Background
Africa has a growing burden of stroke with associated high morbidity and a 3-year fatality rate of 84%. Cardiac disease contributes to stroke occurrence and outcomes, but the precise relationship of abnormalities as noted on a cheap and widely available test, the electrocardiogram (ECG), and acute stroke outcomes have not been previously characterized in Africans.
Objectives
The study assessed the prevalence and prognoses of various ECG abnormalities among African acute stroke patients encountered in a multisite, cross-national epidemiologic study.
Methods
We included 890 patients from Nigeria and Ghana with acute stroke who had 12-lead ECG recording within first 24 h of admission and stroke classified based on brain computed tomography scan or magnetic resonance imaging. Stroke severity at baseline was assessed using the Stroke Levity Scale (SLS), whereas 1-month outcome was assessed using the modified Rankin Scale (mRS).
Results
Patients' mean age was 58.4 ± 13.4 years, 490 were men (55%) and 400 were women (45%), 65.5% had ischemic stroke, and 85.4% had at least 1 ECG abnormality. Women were significantly more likely to have atrial fibrillation, or left ventricular hypertrophy with or without strain pattern. Compared to ischemic stroke patients, hemorrhagic stroke patients were less likely to have atrial fibrillation (1.0% vs. 6.7%; p = 0.002), but more likely to have left ventricular hypertrophy (64.4% vs. 51.4%; p = 0.004). Odds of severe disability or death at 1 month were higher with severe stroke (AOR: 2.25; 95% confidence interval: 1.44 to 3.50), or atrial enlargement (AOR: 1.45; 95% confidence interval: 1.04 to 2.02).
Conclusions
About 4 in 5 acute stroke patients in this African cohort had evidence of a baseline ECG abnormality, but presence of any atrial enlargement was the only independent ECG predictor of death or disability.
Document Type
Article
Publication Date
6-2017
Digital Object Identifier (DOI)
https://doi.org/10.1016/j.gheart.2017.01.002
Funding Information
This work is supported by the National Institutes of Health (NIH) and National Institute of Neurological Disorders and Stroke (NINDS) (Grant 1U54HG007479).
Repository Citation
Adeoye, Abiodun M.; Ogah, Okechukwu S.; Ovbiagele, Bruce; Akinyemi, Rufus; Shidali, Vincent; Agyekum, Francis; Aje, Akinyemi; Adebayo, Oladimeji; Akinyemi, Joshua O.; Kolo, Philip; Appiah, Lambert Tetteh; Iheonye, Henry; Kelechukwu, Uwanuruochi; Ganiyu, Amusa; Olunuga, Taiwo O.; Akpa, Onoja; Olagoke, Ojo Olakanmi; Sarfo, Fred Stephen; Wahab, Kolawole; Olowookere, Samuel; Fakunle, Adekunle; Akpalu, Albert; Adebayo, Philip B.; Nkromah, Kwadwo; Yaria, Joseph; Ibinaiye, Philip; Ogbole, Godwin; Olumayowa, Aridegbe; Lakoh, Sulaiman; Calys-Tagoe, Benedict; and Arnett, Donna K., "Prevalence and Prognostic Features of ECG Abnormalities in Acute Stroke: Findings From the SIREN Study Among Africans" (2017). Epidemiology and Environmental Health Faculty Publications. 44.
https://uknowledge.uky.edu/epidemiology_facpub/44
Notes/Citation Information
Published in Global Heart, v. 12, issue 2, p. 99-105.
© 2017 World Heart Federation (Geneva). Published by Elsevier Ltd. All rights reserved.
This manuscript version is made available under the CC‐BY‐NC‐ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/.
The document available for download is the authors’ post-peer-review final draft of the article. Its title is “Prevalence and Prognostic features of Electrocardiographic Abnormalities in Acute Stroke among Africans: Findings from SIREN.”
Due to the large number of authors, only the first 30 and the authors affiliated with the University of Kentucky are listed in the author section above. For the complete list of authors, please download this article or visit: https://doi.org/10.1016/j.gheart.2017.01.002