The Neighborhoods Study

Authors

• Grace C. George, University of Wisconsin-MadisonFollow
• Sarah A. Keller, University of Wisconsin-Madison
• Erin Abner, University of KentuckyFollow
• Sara Adar, University of Michigan School of Public Health
• Michael L. Alosco, Boston Medical Center
• Liana G. Apostolova, Indiana University School of Medicine
• Kelly Bakulski, University of Michigan School of Public Health
• Lisa L. Barnes, Rush University
• James R. Bateman, Wake Forest School of Medicine
• Stuart Batterman, University of Michigan School of Public Health
• Thomas G. Beach, Banner Sun Health Research Institute
• Barbara B. Bendlin, University of Wisconsin-Madison
• David A. Bennett, Rush University
• Tobey J. Betthauser, University of Wisconsin-Madison
• James Brewer, University of California San Diego Health
• William Buckingham, University of Wisconsin-Madison
• Carmen I. Carrión, Yale University
• Joshua Chodosh, New York University
• Suzanne Craft, Indiana University School of Medicine
• Raina Croff, Oregon Health and Science University
• Anthony Fabio, University of Pittsburgh
• Sarah Tomaszewski Farias, University of California
• Eva L. Feldman, University of Michigan Medical School
• Felicia Goldstein, Emory University
• Stephen A. Goutman, University of Michigan Medical School
• Gina Green-Harris, University of Wisconsin-Madison
• Victor Henderson, Stanford University
• Thomas K. Karikari, University of Pittsburgh

Abstract

INTRODUCTION: The Neighborhoods Study (TNS) is a novel investigation of adverse social exposome and brain health leveraging 22 Alzheimer's Disease Research Centers (ADRCs). TNS aims to understand if the adverse social exposures increase Alzheimer's disease and related dementias (ADRD) risk. METHODS: TNS uses innovative methods to determine lifetime addresses of living (n = ≈ 3116) and brain bank cohorts (n = ≈ 8637). Addresses are linked to time-concordant adverse social exposome using the Area Deprivation Index (ADI) and summarized over time. Brain health measures are provided by the National Alzheimer's Coordinating Center. RESULTS: We highlight a general overview and methodology of TNS. Data collection is ongoing; however, preliminary findings indicate that the adverse social exposome is related to ADRD biomarkers, neuropathology, and cognitive function. DISCUSSION: TNS is the largest study of adverse social exposome and ADRD, using the ADRC network to build robust scientific consortia. Its findings will inform ADRD interventions, precision medicine, and policy. Highlights: The Neighborhoods Study (TNS) investigates adverse social exposome and brain health. TNS is a collaboration among 22 Alzheimer's Disease Research Centers. TNS will give insight on environmental and exposomal factors which may be modifiable. Participant lifetime addresses are linked to temporal adverse social exposome metrics. This study's findings will inform precision approaches to mitigate dementia risk.

Document Type

Article

Publication Date

11-1-2025

Notes/Citation Information

Publisher Copyright: © 2025 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.

Digital Object Identifier (DOI)

10.1002/alz.70810

Archival?

Archival

Repository Citation

George, Grace C.; Keller, Sarah A.; Abner, Erin; Adar, Sara; Alosco, Michael L.; Apostolova, Liana G.; Bakulski, Kelly; Barnes, Lisa L.; Bateman, James R.; Batterman, Stuart; Beach, Thomas G.; Bendlin, Barbara B.; Bennett, David A.; Betthauser, Tobey J.; Brewer, James; Buckingham, William; Carrión, Carmen I.; Chodosh, Joshua; Craft, Suzanne; Croff, Raina; Fabio, Anthony; Farias, Sarah Tomaszewski; Feldman, Eva L.; Goldstein, Felicia; Goutman, Stephen A.; Green-Harris, Gina; Henderson, Victor; and Karikari, Thomas K., "The Neighborhoods Study" (2025). Epidemiology and Environmental Health Faculty Publications. 147.
https://uknowledge.uky.edu/epidemiology_facpub/147