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Abstract
In most multicellular organisms, the structure and content of the genome is rigorously maintained over the course of development. However some species have evolved genome biologies that permit, or require, developmentally regulated changes in the physical structure and content of the genome (programmed genome rearrangement: PGR). Relatively few vertebrates are known to undergo PGR, although all agnathans surveyed to date (several hagfish and one lamprey: Petromyzon marinus) show evidence of large scale PGR. To further resolve the ancestry of PGR within vertebrates, we developed probes that allow simultaneous tracking of nearly all sequences eliminated by PGR in P. marinus and a second lamprey species (Entosphenus tridentatus). These comparative analyses reveal conserved subcellular structures (lagging chromatin and micronuclei) associated with PGR and provide the first comparative embryological evidence in support of the idea that PGR represents an ancient and evolutionarily stable strategy for regulating inherent developmental/genetic conflicts between germline and soma.
Document Type
Article
Publication Date
9-1-2017
Digital Object Identifier (DOI)
https://doi.org/10.1016/j.ydbio.2017.06.032
Funding Information
Research reported in this publication was supported by the National Institute of General Medical Sciences of the National Institutes of Health under award number R01GM104123.
Repository Citation
Timoshevskiy, Vladimir A.; Lampman, Ralph T.; Hess, Jon E.; Porter, Laurie L.; and Smith, Jeramiah J., "Deep Ancestry of Programmed Genome Rearrangement in Lampreys" (2017). Biology Faculty Publications. 167.
https://uknowledge.uky.edu/biology_facpub/167
Notes/Citation Information
Published in Developmental Biology, v. 429, issue 1, p. 31-34.
© 2017 Elsevier Inc.
This manuscript version is made available under the CC‐BY‐NC‐ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/.
The document available for download is the author's post-peer-review final draft of the article.