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Submissions from 2021

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Machine Intelligence Identifies Soluble TNFa as a Therapeutic Target for Spinal Cord Injury, J. R. Huie, A. R. Ferguson, N. Kyritsis, J. Z. Pan, K.-A. Irvine, J. L. Nielson, P. G. Schupp, M. C. Oldham, John C. Gensel, A. Lin, M. R. Segal, R. R. Ratan, J. C. Bresnahan, and M. S. Beattie

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Arginase 1 Insufficiency Precipitates Amyloid-β Deposition and Hastens Behavioral Impairment in a Mouse Model of Amyloidosis, Chao Ma, Jerry B. Hunt, Maj-Linda B. Selenica, Awa Sanneh, Leslie A. Sandusky-Beltran, Mallory Watler, Rana Daas, Andrii Kovalenko, Huimin Liang, Devon Placides, Chuanhai Cao, Xiaoyang Lin, Michael B. Orr, Bei Zhang, John C. Gensel, David J. Feola, Marcia N. Gordon, Dave Morgan, Paula C. Bickford, and Daniel C. Lee

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Genetic Approach to Elucidate the Role of Cyclophilin D in Traumatic Brain Injury Pathology, Ryan D. Readnower, W. Brad Hubbard, Olivia J. Kalimon, James W. Geddes, and Patrick G. Sullivan

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Dystrophic Microglia Are Associated with Neurodegenerative Disease and not Healthy Aging in the Human Brain, Ryan K. Shahidehpour, Rebecca E. Higdon, Nicole G. Crawford, Janna H. Neltner, Eseosa T. Ighodaro, Ela Patel, Douglas Price, Peter T. Nelson, and Adam D. Bachstetter

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Mitochondria Exert Age-Divergent Effects on Recovery from Spinal Cord Injury, Andrew N. Stewart, Katelyn E. McFarlane, Hemendra J. Vekaria, William M. Bailey, Stacey A. Slone, Lauren A. Tranthem, Bei Zhang, Samir P. Patel, Patrick G. Sullivan, and John C. Gensel

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Immunomodulatory Effects of Azithromycin Revisited: Potential Applications to COVID-19, Vincent J. Venditto, Dalia Haydar, Ahmed K. Abdel-Latif, John C. Gensel, Michael I. Anstead, Michelle G. Pitts, Jarrod W. Creameans, Timothy J. Kopper, Chi Peng, and David J. Feola

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Temporal Changes in Inflammatory Mitochondria-Enriched MicroRNAs Following Traumatic Brain Injury and Effects of miR-146a Nanoparticle Delivery, Wang-Xia Wang, Pareshkumar Prajapati, Hemendra J. Vekaria, Malinda Spry, Amber L. Cloud, Patrick G. Sullivan, and Joe E. Springer

Submissions from 2020

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Liposomal Delivery of Azithromycin Enhances Its Immunotherapeutic Efficacy and Reduces Toxicity in Myocardial Infarction, Ahmed Al-Darraji, Renée R. Donahue, Himi Tripathi, Hsuan Peng, Bryana M. Levitan, Lakshman Chelvarajan, Dalia Haydar, Erhe Gao, David Henson, John C. Gensel, David J. Feola, Vincent J. Venditto, and Ahmed K. Abdel-Latif

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Microglial-Associated Responses to Comorbid Amyloid Pathology and Hyperhomocysteinemia in an Aged Knock-in Mouse Model of Alzheimer's Disease, David J. Braun, Edgardo R. Dimayuga, Josh M. Morganti, and Linda J. Van Eldik

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Modulation of Epileptogenesis: A Paradigm for the Integration of Enzyme-Based Microelectrode Arrays and Optogenetics, Corwin R. Butler, Jeffery A. Boychuk, Francois Pomerleau, Ramona Alcala, Peter Huettl, Yi Ai, Johan Jakobsson, Sidney W. Whiteheart, Greg A. Gerhardt, Bret N. Smith, and John T. Slevin

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Optimization and Validation of a Modified Radial-Arm Water Maze Protocol Using a Murine Model of Mild Closed Head Traumatic Brain Injury, Teresa Macheda, Kelly N. Roberts, Josh M. Morganti, David J. Braun, and Adam D. Bachstetter

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Considerations for Studying Sex as a Biological Variable in Spinal Cord Injury, Andrew N. Stewart, Steven M. MacLean, Arnold J. Stromberg, Jessica P. Whelan, William M. Bailey, John C. Gensel, and Melinda E. Wilson

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First-in-Human Studies of MW01-6-189WH, a Brain-Penetrant, Antineuroinflammatory Small-Molecule Drug Candidate: Phase 1 Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Studies in Healthy Adult Volunteers, Linda J. Van Eldik, Lumy Sawaki, Karen Bowen, Daniel T. Laskowitz, Robert J. Noveck, Byron Hauser, Lynn Jordan, Tracy G. Spears, Huali Wu, Kevin Watt, Shruti Raja, Saktimayee M. Roy, D. Martin Watterson, and Jeffrey T. Guptill

Submissions from 2019

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Rediscovering the Axolotl as a Model for Thyroid Hormone Dependent Development, Anne Crowner, Shivam Khatri, Dana Blichmann, and S. Randal Voss

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Efficacy of Leukemia Inhibitory Factor as a Therapeutic for Permanent Large Vessel Stroke Differs among Aged Male and Female Rats, Stephanie M. Davis, Lisa A. Collier, Sarah J. Goodwin, Douglas E. Lukins, David K. Powell, and Keith R. Pennypacker

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Effects of the Dual Orexin Receptor Antagonist DORA-22 on Sleep in 5XFAD Mice, Marilyn J. Duncan, Hannah Farlow, Chairtra Tirumalaraju, Do-Hyun Yun, Chanung Wang, James A. Howard, Madison N. Sanden, Bruce F. O'Hara, Kristen J. McQuerry, and Adam D. Bachstetter

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Deletion of p38α MAPK in Microglia Blunts Trauma-Induced Inflammatory Responses in Mice, Josh M. Morganti, Danielle S. Goulding, and Linda J. Van Eldik

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Chronic Muscle Weakness and Mitochondrial Dysfunction in the Absence of Sustained Atrophy in a Preclinical Sepsis Model, Allison M. Owen, Samir P. Patel, Jeffrey D. Smith, Beverly K. Balasuriya, Stephanie F. Mori, Gregory S. Hawk, Arnold J. Stromberg, Naohide Kuriyama, Masao Kaneki, Alexander G. Rabchevsky, Timothy A. Butterfield, Karyn A. Esser, Charlotte A. Peterson, Marlene E. Starr, and Hiroshi Saito

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Rediscovery of the Endangered Carchi Andean Toad, Rhaebo colomai (Hoogmoed, 1985), in Ecuador, with Comments on Its Conservation Status and Extinction Risk, Carolina Reyes-Puig, Gabriela B. Bittencourt-Silva, María Torres-Sánchez, Mark Wilkinson, Jeffrey W. Streicher, Simon T. Maddock, Ramachandran Kotharambath, Hendrik Müller, Francesca Nicole Angiolani Larrera, Diego Amieda-Reinoso, Santiago R. Ron, and Diego Francisco Cisneros-Heredia

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A Chromosome-Scale Assembly of the Axolotl Genome, Jeramiah J. Smith, Nataliya Y. Timoshevskaya, Vladimir A. Timoshevskiy, Melissa C. Keinath, Drew Hardy, and S. Randal Voss

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Multi-Tissue Transcriptomes of Caecilian Amphibians Highlight Incomplete Knowledge of Vertebrate Gene Families, María Torres-Sánchez, Christopher J. Creevey, Etienne Kornobis, David J. Gower, Mark Wilkinson, and Diego San Mauro

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What Lies Beneath? Molecular Evolution During the Radiation of Caecilian Amphibians, María Torres-Sánchez, David J. Gower, David Alvarez-Ponce, Christopher J. Creevey, Mark Wilkinson, and Diego San Mauro

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HDAC Regulates Transcription at the Outset of Axolotl Tail Regeneration, S. Randal Voss, Larissa V. Ponomareva, Varun B. Dwaraka, Kaitlin E. Pardue, Nour W. Al Haj Baddar, A. Katherine Rodgers, M. Ryan Woodcock, Qingchao Qiu, Anne Crowner, Dana Blichmann, Shivam Khatri, and Jon S. Thorson

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Simulated Biological Fluid Exposure Changes Nanoceria’s Surface Properties but not its Biological Response, Robert A. Yokel, Matthew L. Hancock, Benjamin Cherian, Alexandra J. Brooks, Marsha L. Ensor, Hemendra J. Vekaria, Patrick G. Sullivan, and Eric A. Grulke

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Macrolide Derivatives Reduce Proinflammatory Macrophage Activation and Macrophage‐Mediated Neurotoxicity, Bei Zhang, Timothy J. Kopper, Xiaodong Liu, Zheng Cui, Steven G. Van Lanen, and John C. Gensel