Protocol of a randomized trial of “pathways,” a hope intervention for people undergoing treatment for advanced lung cancer

Authors

• Laurie E. McLouth, University of KentuckyFollow
• Courtney Blair, University of Kentucky HealthCareFollow
• Brent J. Shelton, University of KentuckyFollow
• Jennifer S. Cheavens, Ohio State University
• Vilma Bursac, University of Kentucky HealthCareFollow
• Jessica L. Burris, University of KentuckyFollow
• Amy H. Peterman, University of North Carolina at Charlotte
• Jessica McFarlin, University of KentuckyFollow
• Jerod L. Stapleton, University of KentuckyFollow
• Lynn Andreae, University of Kentucky College of MedicineFollow
• Lauren Corum, University of Kentucky HealthCareFollow
• Amy Cowley, University of Kentucky College of MedicineFollow
• Susanne M. Arnold, University of KentuckyFollow

Abstract

Objective: Advanced cancer and its treatment can disrupt personal goal pursuits and attainment, which can imperil patient quality of life and increase risk for depression. Hope interventions foster the goal-pursuit skills exemplified by high-hope individuals and, based on a pilot trial, are a promising approach to support these patients. The current Phase II trial (NCT06047301) aims to determine the efficacy of a brief, hope intervention, “Pathways,” in improving depression symptoms for people undergoing treatment advanced stage lung cancer with elevated distress. Methods: In this two-arm randomized controlled trial, 234 people undergoing treatment for advanced stage lung cancer are randomized to Pathways or enhanced usual care. The Pathways intervention consists of a cancer resource guide and five sessions (150–180 min total) delivered primarily during infusion or by phone by nurse practitioners or social workers. Sessions focus on identifying values, setting goals, building pathways, and agency thinking. Enhanced usual care consists of receiving and reviewing the cancer resource guide with staff. Outcomes are assessed at baseline, mid-intervention, and at 2-, 6-, and 12-weeks post-intervention. The primary outcome is depression symptoms at 2 weeks. Secondary outcomes include measures of anxiety, demoralization, positive affect, meaning and peace, social and role function, and quality of life. Results: Recruitment began in November 2023; 94 patients have enrolled as of November 5, 2025. Conclusion: If efficacious, Pathways may be a pragmatic point-of-care intervention to address cancer-related goal disruption and ultimately support the mental health and quality of life of patients receiving treatment for advanced lung cancer.

Document Type

Article

Publication Date

11-1-2026

Notes/Citation Information

Publisher Copyright: © 2026 Published by Elsevier Inc.

Digital Object Identifier (DOI)

10.1016/j.cct.2026.108447

Archival?

Archival

Repository Citation

McLouth, Laurie E.; Blair, Courtney; Shelton, Brent J.; Cheavens, Jennifer S.; Bursac, Vilma; Burris, Jessica L.; Peterman, Amy H.; McFarlin, Jessica; Stapleton, Jerod L.; Andreae, Lynn; Corum, Lauren; Cowley, Amy; and Arnold, Susanne M., "Protocol of a randomized trial of “pathways,” a hope intervention for people undergoing treatment for advanced lung cancer" (2026). Psychology Faculty Publications. 271.
https://uknowledge.uky.edu/psychology_facpub/271