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US Patent Number
6495354
Publication Date
12-17-2002
Abstract
Novel synthases and the corresponding nucleic acids encoding such synthases are disclosed herein. Such synthases possess an active site pocket that includes key amino acid residues that are modified to generate desired terpenoid reaction intermediates and products. Synthase modifications are designed based on, e.g., the three-dimensional coordinates of tobacco 5-epi-aristolochene synthase with or without a substrate bound in the active site.
Assignees
University of Kentucky Research Foundation, Lexington, KY (US), The Salk Institute for Biological Studies, San Diego, CA (US)
Application Number
09/887,586
Filing Date
06/22/2001
Recommended Citation
Chappell, Joseph; Manna, Kathleen R.; Noel, Joseph P.; and Starks, Courtney M., "Synthases" (2002). Pharmaceutical Sciences Faculty Patents. 67.
https://uknowledge.uky.edu/ps_patents/67
