Title

Synthases

US Patent Number

6645762

Publication Date

11-11-2003

Abstract

Novel synthases and the corresponding nucleic acids encoding such synthases are disclosed herein. Such synthases possess an active site pocket that includes key amino acid residues that are modified to generate desired terpenoid reaction intermediates and products. Synthase modifications are designed based on, e.g., the three-dimensional coordinates of tobacco 5-epi-aristolochene synthase, with or without a substrate bound in the active site.

Assignees

The Salk Institute for Biological Studies, La Jolla, CA (US), University of Kentucky Research Foundation, Lexington, KY (US)

Application Number

09/900,797

Filing Date

07/06/2001

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