US Patent Number
6645762
Publication Date
11-11-2003
Abstract
Novel synthases and the corresponding nucleic acids encoding such synthases are disclosed herein. Such synthases possess an active site pocket that includes key amino acid residues that are modified to generate desired terpenoid reaction intermediates and products. Synthase modifications are designed based on, e.g., the three-dimensional coordinates of tobacco 5-epi-aristolochene synthase, with or without a substrate bound in the active site.
Assignees
The Salk Institute for Biological Studies, La Jolla, CA (US), University of Kentucky Research Foundation, Lexington, KY (US)
Application Number
09/900,797
Filing Date
07/06/2001
Recommended Citation
Chappell, Joseph; Manna, Kathleen R.; Noel, Joseph P.; and Starks, Courtney M., "Synthases" (2003). Pharmaceutical Sciences Faculty Patents. 64.
https://uknowledge.uky.edu/ps_patents/64
