US Patent Number
7642369
Publication Date
1-5-2010
Abstract
An efficient new route for the preparation of dihydroeponemycin, an active eponemycin derivative, is provided, which includes the synthesis of the intermediate compound, a hydroxymethyl-substituted enone. In addition, a method is provided for synthesizing inhibitors, which includes PI′-modified analogues. These analogues selectively bind to a major immunoproteasome catalytic subunit LMP2 and inactivate its proteolytic activity in a method of treating diseases, including myeloma and other cancers, Huntington's disease and Alzheimer's disease.
Assignees
University of Kentucky Research Foundation, Lexington, KY (US)
Application Number
11/531,129
Filing Date
09/12/2006
Recommended Citation
Kim, Kyung Bo and Ho, Yik Khuan, "Epoxyketone-Based Immunoproteasome Inhibitors" (2010). Pharmaceutical Sciences Faculty Patents. 50.
https://uknowledge.uky.edu/ps_patents/50
