Archived
This content is available here strictly for research, reference, and/or recordkeeping and as such it may not be fully accessible. If you work or study at University of Kentucky and would like to request an accessible version, please use the SensusAccess Document Converter.
US Patent Number
7642369
Publication Date
1-5-2010
Abstract
An efficient new route for the preparation of dihydroeponemycin, an active eponemycin derivative, is provided, which includes the synthesis of the intermediate compound, a hydroxymethyl-substituted enone. In addition, a method is provided for synthesizing inhibitors, which includes PI′-modified analogues. These analogues selectively bind to a major immunoproteasome catalytic subunit LMP2 and inactivate its proteolytic activity in a method of treating diseases, including myeloma and other cancers, Huntington's disease and Alzheimer's disease.
Assignees
University of Kentucky Research Foundation, Lexington, KY (US)
Application Number
11/531,129
Filing Date
09/12/2006
Recommended Citation
Kim, Kyung Bo and Ho, Yik Khuan, "Epoxyketone-Based Immunoproteasome Inhibitors" (2010). Pharmaceutical Sciences Faculty Patents. 50.
https://uknowledge.uky.edu/ps_patents/50
