US Patent Number
A method for preparing a site-specific peptide probe, wherein the peptide is specific to a receptor, includes modifying a marker to include a tether molecule and covalently binding the tether molecule to the peptide. The present invention also provides a labeled probe, comprising a peptide specific for a receptor and a marker. The marker is modified to include a tether molecule capable of covalently binding to the peptide. The peptide is typically derived from a bacteriophage or is a synthetic analog or derivative of the peptide. The receptor will typically be found on a surface of a bacterial cell. The method and probe of the invention are suitable for a rapid assay for a bacteria in a complex mixture.
University of Kentucky Research Foundation, Lexington, KY (US)
Hicks, Clair D. and Crooks, Peter A., "Bioactive Peptide-Based Probes" (2010). Pharmaceutical Sciences Faculty Patents. 42.