US Patent Number
The presently-disclosed subject matter includes isolated polypeptides that comprise a butyrylcholinestrase (BChE) polypeptide and a second polypeptide. The BChE polypeptide as well as the second polypeptide can be variants and/or fragments thereof. The presently-disclosed subject matter also includes a pharmaceutical composition that comprises the present isolated polypeptide and a suitable pharmaceutical carrier. Further still, methods are provided for treating cocaine-induced conditions, and comprise administering the isolated polypeptide and/or pharmaceutical compositions thereof to an individual.
University of Kentucky Research Foundation, Lexington, KY (US)
Zhan, Chang-Guo; Zheng, Fang; Tai, Hsin-Hsiung; Chen, Xiabin; Xue, Liu; and Hou, Shurong, "Cocaine Hydrolase-Fc Fusion Proteins for Cocaine and Methods for Utilizing the Same" (2020). Pharmaceutical Sciences Faculty Patents. 192.