US Patent Number
10,975,412
Publication Date
4-13-2021
Abstract
A method is described for the identification o f multi-subunit biocomplex drug targets. The method includes identifying a target that performs a biological function, wherein the target comprises one or more subunits, wherein a minimum number of the one or more subunits is inactivated to inhibit the biological function. The method includes selecting a drug that binds specifically to each subunit of the one or more subunits with a target probability. The method describes a relationship between inhibition efficiency of the drug and total number of the one or more subunits using a binomial distribution, wherein the inhibition efficiency comprises a probability that the delivered drug blocks the biological function. The method includes confirming empirically the relationship using an experimental target. The method includes administering the drug to the target to treat a multi-drug resistant disease, wherein the target comprises a biological complex in a mammalian subject.
Assignees
University of Kentucky Research Foundation, Lexington, KY (US)
Application Number
15/572,038
Filing Date
5-6-2016
Recommended Citation
Guo, Peixuan and Shu, Dan, "Method for Designing Compounds and Compositions Useful for Targeting High Stoichiometric Complexes to Treat Conditions, Including Treatment of Viruses, Bacteria, and Cancers Having Acquired Drug Resistance" (2021). Pharmaceutical Sciences Faculty Patents. 191.
https://uknowledge.uky.edu/ps_patents/191
