US Patent Number
8592193
Publication Date
11-26-2013
Abstract
Butyrylcholinesterase (BChE) polypeptide variants of the presently-disclosed subject matter have enhanced catalytic efficiency for (−)-cocaine, as compared to wild-type BChE. Pharmaceutical compositions of the presently-disclosed subject matter include a BChE polypeptide variant having an enhanced catalytic efficiency for (−)-cocaine. A method of the presently-disclosed subject matter for treating a cocaine-induced condition includes administering to an individual an effective amount of a BChE polypeptide variant, as disclosed herein, to lower blood cocaine concentration.
Assignees
University of Kentucky Research Foundation, Lexington, KY (US)
Application Number
13/399,406
Filing Date
02/17/2012
Recommended Citation
Zhan, Chang-Guo; Zheng, Fang; Yang, Wenchao; Xue, Lin; and Hou, Shurong, "High Activity Mutants of Butyrylcholinesterase for Cocaine Hydrolysis" (2013). Pharmaceutical Sciences Faculty Patents. 17.
https://uknowledge.uky.edu/ps_patents/17
