Synthesis and Use of Diagnostic Radio-Pharmaceuticals Comprising Radioactive Isotopes of Bromine with Dyes

Authors

John W. Triplett, University of Kentucky
Randall B. Smith, University of Kentucky

US Patent Number

4256727

Publication Date

3-17-1981

Abstract

A process for preparing bromine-containing dyes labelled with gamma-emitting isotopes of bromine, and the product thereof which is useful as an imaging agent for the hepato-biliary system, particularly in dynamic imaging methods. The dyes prepared are from the class of triarylmethane dyes, and also from the phthalein subclass of the class of xanthene dyes, and the labelling thereof is effected with ⁷⁶Br, ⁷⁷ Br or ⁸² Br. The process for preparing these dyes involves reacting the non-brominated dye precursor with either ⁷⁶ Br₂, ⁷⁷ Br₂ or ⁸² Br₂. This is a substitution type of reaction in which a ring hydrogen is substituted by either ⁷⁶ Br, ⁷⁷ Br or ⁸² Br.

Assignees

University of Kentucky Research Foundation, Lexington, Ky.

Application Number

943,555

Filing Date

09/18/1978

Recommended Citation

Triplett, John W. and Smith, Randall B., "Synthesis and Use of Diagnostic Radio-Pharmaceuticals Comprising Radioactive Isotopes of Bromine with Dyes" (1981). Pharmaceutical Sciences Faculty Patents. 150.
https://uknowledge.uky.edu/ps_patents/150