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US Patent Number
8206703
Publication Date
6-26-2012
Abstract
Butyrylcholinesterase (BChE) polypeptide variants of the presently-disclosed subject matter have enhanced catalytic efficiency for (−)-cocaine, as compared to wild-type BChE. Pharmaceutical compositions of the presently-disclosed subject matter include a BChE polypeptide variant having an enhanced catalytic efficiency for (−)-cocaine. A method of the presently-disclosed subject matter for treating a cocaine-induced condition includes administering to an individual an effective amount of a BChE polypeptide variant, as disclosed herein, to lower blood cocaine concentration.
Assignees
University of Kentucky Research Foundation, Lexington, KY (US)
Application Number
13/005,213
Filing Date
01/12/2011
Recommended Citation
Zhan, Chang-Guo; Zheng, Fang; and Yang, Wenchao, "High Activity Mutants of Butyrylcholinesterase for Cocaine Hydrolysis" (2012). Pharmaceutical Sciences Faculty Patents. 14.
https://uknowledge.uky.edu/ps_patents/14
