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US Patent Number
4741872
Publication Date
5-3-1988
Abstract
A method for preparing biodegradable microspheres having a three-dimensional network in which biologically active macromolecular agents are physically entrapped therein. The microsphere is able to degrade and release the macromolecular agent at a controlled rate. The method involves emulsifying a vinyl derivative of a biodegradable hydrophilic polymer, a water-soluble monovinyl monomer and a biologically active macromolecule in water, and copolymerizing the biodegradable hydrophilic polymer and the water-soluble monovinyl monomer such that the biologically active macromolecule is entrapped therein.
Assignees
University of Kentucky Research Foundation, Lexington, Ky.
Application Number
864,147
Filing Date
05/16/1986
Recommended Citation
DeLuca, Patrick P. and Rypacek, Frantisek, "Preparation of Biodegradable Microspheres Useful as Carriers for Macromolecules" (1988). Pharmaceutical Sciences Faculty Patents. 129.
https://uknowledge.uky.edu/ps_patents/129
