US Patent Number
7691872
Publication Date
4-6-2010
Abstract
The present invention provides methods and formulations for optimizing the anti-cancer and anti-HIV activities of a camptothecin drug, including camptothecin and its related analogs including 9-aminocamptothecin and 9-nitrocamptothecin. The invention involves methodologies and formulations that limit human serum albumin-mediated reduction of the anti-cancer and anti-HIV effects of the camptothecins, and the methods and formulations provide combination therapies in which binding of the camptothecin agent to human serum albumin can be modulated by the administration of a competing agent that also binds human serum albumin. Reduced camptothecin drug binding to human serum albumin can result in elevated camptothecin free drug levels and thus improve the effectiveness of treatment regimens involving these drugs. Further agents such as methotrexate and AZT can also be used in cancer and HIV-positive patients employing camptothecin drugs.
Assignees
University of Kentucky Research Foundation, Lexington, KY (US), New Century Pharmaceuticals, Inc., Huntsville, AL (US)
Application Number
10/101,513
Filing Date
03/20/2002
Recommended Citation
Burke, Thomas G. and Carter, Daniel C., "Methods and Compositions for Optimizing Blood and Tissue Stability of Camptothecin and Other Albumin-Binding Therapeutic Compounds" (2010). Pharmaceutical Sciences Faculty Patents. 113.
https://uknowledge.uky.edu/ps_patents/113
