US Patent Number
5824774
Publication Date
10-20-1998
Abstract
Disclosed is a chimeric isoprenoid synthase polypeptide including a first domain from a first isoprenoid synthase joined to a second domain from a second, heterologous isoprenoid synthase, whereby the chimeric isoprenoid synthase is capable of catalyzing the production of isoprenoid reaction products that are not produced in the absence of the second domain of the second, heterologous isoprenoid synthase. Also disclosed is a chimeric isoprenoid synthase polypeptide including an assymetrically positioned homologous domain, whereby the chimeric isoprenoid synthase is capable of catalyzing the production of isoprenoid reaction products that are not produced when the domain is positioned at its naturally-occurring site in the isoprenoid synthase polypeptide.
Assignees
Board of Trustees of the University of Kentucky, Lexington, Ky.
Application Number
631,341
Filing Date
04/12/1996
Recommended Citation
Chappell, Joseph and Back, Kyoungwhan, "Chimeric Isoprenoid Synthases and Uses Thereof" (1998). Pharmaceutical Sciences Faculty Patents. 101.
https://uknowledge.uky.edu/ps_patents/101
