Abstract
BACKGROUND: In addition to vertical transmission, organisms can also acquire genes from other distantly related species or from their extra-chromosomal elements (plasmids and viruses) via horizontal gene transfer (HGT). It has been suggested that phages represent substantial forces in prokaryotic evolution. In eukaryotes, retroviruses, which can integrate into host genome as an obligate step in their replication strategy, comprise approximately 8% of the human genome. Unlike retroviruses, few members of other virus families are known to transfer genes to host genomes.
RESULTS: Here we performed a systematic search for sequences related to circular single-stranded DNA (ssDNA) viruses in publicly available eukaryotic genome databases followed by comprehensive phylogenetic analysis. We conclude that the replication initiation protein (Rep)-related sequences of geminiviruses, nanoviruses and circoviruses have been frequently transferred to a broad range of eukaryotic species, including plants, fungi, animals and protists. Some of the transferred viral genes were conserved and expressed, suggesting that these genes have been coopted to assume cellular functions in the host genomes. We also identified geminivirus-like and parvovirus-like transposable elements in genomes of fungi and lower animals, respectively, and thereby provide direct evidence that eukaryotic transposons could derive from ssDNA viruses.
CONCLUSIONS: Our discovery extends the host range of circular ssDNA viruses and sheds light on the origin and evolution of these viruses. It also suggests that ssDNA viruses act as an unforeseen source of genetic innovation in their hosts.
Document Type
Article
Publication Date
9-26-2011
Digital Object Identifier (DOI)
http://dx.doi.org/10.1186/1471-2148-11-276
Repository Citation
Liu, Huiquan; Fu, Yanping; Li, Bo; Yu, Xiao; Xie, Jiatao; Cheng, Jiasen; Ghabrial, Said A.; Li, Guoqing; Yi, Xianhong; and Jiang, Daohong, "Widespread horizontal gene transfer from circular single-stranded DNA viruses to eukaryotic genomes" (2011). Plant Pathology Faculty Publications. 18.
https://uknowledge.uky.edu/plantpath_facpub/18
Additional file 1
1471-2148-11-276-s2.zip (61 kB)
Additional file 2
1471-2148-11-276-s3.pdf (90 kB)
Additional file 3
Notes/Citation Information
Published in BMC Evolutionary Biology, v. 11, 276.
© 2011 Liu et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.