Abstract
In the past five years, a series of large-scale genetic studies have revealed novel risk factors for Alzheimer's disease (AD). Analyses of these risk factors have focused attention upon the role of immune processes in AD, specifically microglial function. In this review, we discuss interpretation of genetic studies. We then focus upon six genes implicated by AD genetics that impact microglial function: TREM2, CD33, CR1, ABCA7, SHIP1, and APOE. We review the literature regarding the biological functions of these six proteins and their putative role in AD pathogenesis. We then present a model for how these factors may interact to modulate microglial function in AD.
Document Type
Review
Publication Date
10-5-2015
Digital Object Identifier (DOI)
http://dx.doi.org/10.1186/s13024-015-0048-1
Repository Citation
Malik, Manasi; Parikh, Ishita; Vasquez, Jared B.; Smith, Conor; Tai, Leon; Bu, Guojun; LaDu, Mary Jo; Fardo, David W.; Rebeck, G. William; and Estus, Steven, "Genetics Ignite Focus on Microglial Inflammation in Alzheimer's Disease" (2015). Physiology Faculty Publications. 71.
https://uknowledge.uky.edu/physiology_facpub/71
- Citations
- Citation Indexes: 129
- Patent Family Citations: 1
- Usage
- Downloads: 172
- Abstract Views: 10
- Captures
- Readers: 272
- Mentions
- Blog Mentions: 1
- News Mentions: 3
Notes/Citation Information
Published in Molecular Neurodegeneration, v. 10, article 52, p. 1-12.
© 2015 Malik et al.
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.