Myocardium From Patients With ATTR Amyloidosis Produces Less Force Secondary to Increased Fibrosis

Authors

• Gregory N. Milburn, University of Kentucky College of MedicineFollow
• Jania Bell, University of Kentucky
• Austin G. Wellette-Hunsucker, University of KentuckyFollow
• Hollings Ruml, University of Kentucky
• Andrew T. Yackzan, University of KentuckyFollow
• Kenneth S. Campbell, University of KentuckyFollow

Abstract

Amyloid transthyretin cardiac amyloidosis is one of the most common infiltrative cardiomyopathies. Contractile, biochemical, and histological assays were performed on myocardium from patients with and without amyloid transthyretin amyloidosis. Force was reduced in amyloidosis, but calcium sensitivity was increased. The change in calcium sensitivity may reflect dephosphorylation of troponin I. The proportion of stiffness attributable to the extracellular matrix was larger in amyloidosis. Septal fibrosis and amyloid burden correlated with measurements from LV samples. Technetium pyrophosphate scans may detect increased microcalcifications in amyloidosis myocardium. Replacement of myocytes with extracellular matrix is the most important factor depressing contractile force in amyloidosis myocardium.

Document Type

Article

Publication Date

7-1-2025

Notes/Citation Information

Publisher Copyright: © 2025 The Authors

Digital Object Identifier (DOI)

10.1016/j.jacbts.2025.03.003

Archival?

Archival

Repository Citation

Milburn, Gregory N.; Bell, Jania; Wellette-Hunsucker, Austin G.; Ruml, Hollings; Yackzan, Andrew T.; and Campbell, Kenneth S., "Myocardium From Patients With ATTR Amyloidosis Produces Less Force Secondary to Increased Fibrosis" (2025). Physiology Faculty Publications. 249.
https://uknowledge.uky.edu/physiology_facpub/249