Thyroid hormone augmentation accelerates hair cell maturation in human cochlear organoids

Authors

• Tsubasa Saeki, Indiana University School of Medicine
• Yoshitomo Ueda, Indiana University School of Medicine
• Isabel Aristizábal-Ramírez, University of Kentucky College of MedicineFollow
• Stephen T. Moore, Indiana University School of Medicine
• Rick F. Nelson, Indiana University School of Medicine
• Gregory I. Frolenkov, University of KentuckyFollow
• Eri Hashino, Indiana University School of MedicineFollow

Abstract

Saeki et al. showed that timed supplementation of thyroxine, a thyroid hormone, expedites maturation of outer hair cells in human pluripotent stem cell-derived cochlear organoids. Some of the thyroxine-treated hair cells exhibit nonlinear capacitance, a functional hallmark of outer hair cell electromotility.

Document Type

Article

Publication Date

2-24-2026

Notes/Citation Information

Publisher Copyright: © 2025 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license. http://creativecommons.org/licenses/by-nc-nd/4.0/

Digital Object Identifier (DOI)

10.1016/j.celrep.2025.116898

Archival?

Archival

Repository Citation

Saeki, Tsubasa; Ueda, Yoshitomo; Aristizábal-Ramírez, Isabel; Moore, Stephen T.; Nelson, Rick F.; Frolenkov, Gregory I.; and Hashino, Eri, "Thyroid hormone augmentation accelerates hair cell maturation in human cochlear organoids" (2026). Physiology Faculty Publications. 212.
https://uknowledge.uky.edu/physiology_facpub/212