Abstract
Manganese-enhanced magnetic resonance imaging (MEMRI) rose to prominence in the 1990s as a sensitive approach to high contrast imaging. Following the discovery of manganese conductance through calcium-permeable channels, MEMRI applications expanded to include functional imaging in the central nervous system (CNS) and other body systems. MEMRI has since been employed in the investigation of physiology in many animal models and in humans. Here, we review historical perspectives that follow the evolution of applied MRI research into MEMRI with particular focus on its potential toxicity. Furthermore, we discuss the more current in vivo investigative uses of MEMRI in CNS investigations and the brief but decorated clinical usage of chelated manganese compound mangafodipir in humans.
Document Type
Review
Publication Date
12-13-2018
Digital Object Identifier (DOI)
https://doi.org/10.3389/fnagi.2018.00403
Funding Information
This work was supported by National Institutes of Health (NIH)/NINDS award 1R01NS091329-01A1, U.S. Department of Defense award AZ140097, NIH/NIMH L32 MD009205-01, NIH/NCATS 5UL1TR000117-04 and NIH/NIGMS 5P30GM110787-Pilot.
Repository Citation
Cloyd, Ryan A.; Koren, Shon A.; and Abisambra, Jose F., "Manganese-Enhanced Magnetic Resonance Imaging: Overview and Central Nervous System Applications With a Focus on Neurodegeneration" (2018). Physiology Faculty Publications. 135.
https://uknowledge.uky.edu/physiology_facpub/135
Included in
Bioimaging and Biomedical Optics Commons, Diseases Commons, Geriatrics Commons, Nervous System Commons, Neurosciences Commons, Physiology Commons
Notes/Citation Information
Published in Frontiers in Aging Neuroscience, v. 10, 403, p. 1-22.
© 2018 Cloyd, Koren and Abisambra.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.