Abstract
High-density lipoprotein (HDL) have long been studied for their protective role against cardiovascular diseases, however recently relationship between HDL and cancer came into focus. Several epidemiological studies have shown an inverse correlation between HDL-cholesterol (HDL-C) and cancer risk, and some have even implied that HDL-C can be used as a predictive measure for survival prognosis in for specific sub-population of certain types of cancer. HDL itself is an endogenous nanoparticle capable of removing excess cholesterol from the periphery and returning it to the liver for excretion. One of the main receptors for HDL, scavenger receptor type B-I (SR-BI), is highly upregulated in endocrine cancers, notably due to the high demand for cholesterol by cancer cells. Thus, the potential to exploit administration of cholesterol-free reconstituted or synthetic HDL (sHDL) to deplete cholesterol in endocrine cancer cell and stunt their growth of use chemotherapeutic drug loaded sHDL to target payload delivery to cancer cell has become increasingly attractive. This review focuses on the role of HDL and HDL-C in cancer and application of sHDLs as endocrine cancer therapeutics.
Document Type
Review
Publication Date
11-30-2018
Digital Object Identifier (DOI)
https://doi.org/10.3389/fendo.2018.00715
Funding Information
This publication was made possible by Grant Number R01GM113832 (to AS and X-AL) from NIGMS/NIH and NIH T32-HL125242 (EM).
Repository Citation
Morin, Emily E.; Li, Xiang-An; and Schwendeman, Anna, "HDL in Endocrine Carcinomas: Biomarker, Drug Carrier, and Potential Therapeutic" (2018). Physiology Faculty Publications. 130.
https://uknowledge.uky.edu/physiology_facpub/130
Included in
Amino Acids, Peptides, and Proteins Commons, Cancer Biology Commons, Endocrine System Commons, Endocrine System Diseases Commons, Endocrinology, Diabetes, and Metabolism Commons, Oncology Commons, Physiology Commons, Therapeutics Commons
Notes/Citation Information
Published in Frontiers in Endocrinology, v. 9, 715, p. 1-11.
© 2018 Morin, Li and Schwendeman.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.