Abstract
OBJECTIVE: Relatively few dyad-based studies have evaluated the shared psychosocial and financial toxicity (FT) experiences of hematologic patients and their caregivers, especially those undergoing bone marrow transplantations (BMTs). This study evaluated the association of FT with health-related quality of life (QOL) among BMT patient-caregiver dyads.
METHODS: Survey and electronic health record data were collected between April 2021 and January 2022 from BMT patients and their caregivers pre- (T1) and post-intervention (T2). Thirty-four patient-caregiver dyads completed surveys; all dyads included a patient experiencing elevated T1 FT. The effect of the total FT score (i.e., the combination of psychological response, coping behaviors, and material conditions domain scores) on physical health, mental health, anxiety, depression and distress scores was evaluated using Actor-Partner Interdependence Modeling (APIM).
RESULTS: Patients and caregivers who reported lower total FT scores had better physical and mental health, and lower anxiety, depressive symptoms, distress (APIM actor effects). None of the partner effects were significant in the APIM models. Other model findings indicated that compared with caregivers, patients had lower reported physical health; mental health scores were higher, on average, for all participants at the T2 compared with T1; and members of dyads whose caregiver took time off work reported better physical health and lower depressive symptoms and distress than those whose caregiver did not.
CONCLUSIONS: Our study addresses a significant gap in dyad-based cancer FT studies; the findings underscore the need for additional research to help develop tailored dyad-level FT interventions for improving health-related QOL among BMT patients.
Document Type
Article
Publication Date
2-1-2024
Digital Object Identifier (DOI)
https://doi.org/10.1002/pon.6303
Funding Information
This research was funded by the National Cancer Institute's Administrative supplements for P30 Cancer Center Support Grants to Address Financial Hardship During Cancer Treatment (3P30CA177558-08S4) and supported by the Patient Oriented and Population Science Shared Resource Facilities and Research Communications Office, Markey Cancer Center (P30CA177558). Laurie McLouth was supported by KL2TR001996.
Repository Citation
Edward, Jean S; Rayens, Mary Kay; McLouth, Laurie E.; Eisele, Lori P; Scales, Joan; Williams, Lovoria B.; and Hildebrandt, Gerhard C., "A dyadic analysis of financial toxicity and health-related quality of life among bone marrow transplant patients and their caregivers." (2024). Nursing Faculty Publications. 70.
https://uknowledge.uky.edu/nursing_facpub/70
Notes/Citation Information
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. © 2024 The Authors. Psycho-Oncology published by John Wiley & Sons Ltd.