Abstract
BACKGROUND: Meningiomas are the most common central nervous system tumor. We describe current trends in treatment and survival using the largest cancer dataset in the United States.
METHODS: We analyzed the National Cancer Database from 2004 to 2014, for all patients with diagnosis of meningioma.
RESULTS: 201,765 cases were analyzed. Patients were most commonly White (81.9%) females (73.2%) with a median age of 64 years. Fifty percent of patients were diagnosed by imaging. Patients were reported as grade I (24.9%), grade II (5.0%), grade III (0.7%), or unknown WHO grade (69.4%). Patients diagnosed by imaging were older, received treatment in community facilities, had higher Charlson-Deyo score, and a lower rate of private insurance. Watchful waiting was the most common treatment modality (46.7%), followed by surgery only (40%). Grade II and III patients were more likely to receive therapy. Watchful waiting increased from 35.2% in 2004 to 51.4% in 2014. Younger age, male gender, private insurance, and treatment in academic facilities were determinants for receipt of surgery and/or radiation. Median survival was 12.6 years, higher in histologically confirmed cases (13.1 years). Older patients, Blacks, males, those that received radiation plus surgery, and were treated in community facilities had an increased risk of mortality.
CONCLUSIONS: Over half of patients were diagnosed by imaging, suggesting a higher role of clinical determinants over histological confirmation in treatment decisions. Watchful waiting as initial management is increasing. Our survival analysis favored histological confirmation. Patients receiving radiation and surgery had an increased risk of mortality.
Document Type
Article
Publication Date
6-2019
Digital Object Identifier (DOI)
https://doi.org/10.1016/j.canep.2019.02.018
Funding Information
Ms. Slone is supported by the Biostatistics and Bioinformatics Shared Resource of the University of Kentucky Markey Cancer Center (P30 CA177558).
Repository Citation
Garcia, Catherine R.; Slone, Stacey A.; Chau, Monica; Neltner, Janna H.; Pittman, Thomas A.; and Villano, John L., "Initial Management of Meningiomas: Analysis of the National Cancer Database" (2019). Neurology Faculty Publications. 60.
https://uknowledge.uky.edu/neurology_facpub/60
Supplementary materials
Included in
Internal Medicine Commons, Neurology Commons, Neurosurgery Commons, Oncology Commons, Pathology Commons
Notes/Citation Information
Published in Cancer Epidemiology, v. 60.
© 2019 Elsevier Ltd.
© 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/