Status Epilepticus Alert Reduces Time to Administration of Second-Line Antiseizure Medications

Authors

Mauricio F. Villamar, University of KentuckyFollow
Aaron M. Cook, University of KentuckyFollow
Chenlu Ke, University of KentuckyFollow
Yan Xu, University of KentuckyFollow
Jordan L. Clay, University of Kentucky
Katelyn S Dolbec, University of Kentucky
Rachel Ward-Mitchell, University of KentuckyFollow
Larry B. Goldstein, University of KentuckyFollow
Meriem Bensalem-Owen, University of KentuckyFollow

Abstract

Background: Status epilepticus (SE) is a neurologic emergency with high morbidity and mortality. Delays in SE treatment are common in clinical practice and can be associated with poorer outcomes. Our goal was to determine whether the implementation of an SE alert protocol improves time to administration of a second-line antiseizure medication (ASM) in hospitalized adults.

Methods: We developed and implemented an inpatient SE alert system. A quasiexperimental cohort study was performed. We analyzed all patients aged 18-85 years who were managed at the University of Kentucky Medical Center using the SE alert protocol between March 2015 and June 2017 (n = 19). Controls were the first 20 consecutive patients treated for SE over the same time period, but who were managed with usual care (i.e., without SE alert protocol).

Results: Time to administration of a second-line ASM was shorter with the use of the SE alert system (22.21 ± 3.44 minutes) compared to usual care (58.30 ± 6.72 minutes; p < 0.0001).

Conclusion: Implementation of an SE alert system led to a marked improvement in time to administration of a second-line ASM.

Classification of evidence: This study provides Class III evidence that for adult inpatients treated for SE, implementation of an SE alert protocol reduces time to administration of second-line ASM.

Document Type

Article

Publication Date

12-2018

Notes/Citation Information

Published in Neurology Clinical Practice, v. 8, issue 6.

© 2018 American Academy of Neurology

Digital Object Identifier (DOI)

https://doi.org/10.1212/CPJ.0000000000000544

Repository Citation

Villamar, Mauricio F.; Cook, Aaron M.; Ke, Chenlu; Xu, Yan; Clay, Jordan L.; Dolbec, Katelyn S; Ward-Mitchell, Rachel; Goldstein, Larry B.; and Bensalem-Owen, Meriem, "Status Epilepticus Alert Reduces Time to Administration of Second-Line Antiseizure Medications" (2018). Neurology Faculty Publications. 38.
https://uknowledge.uky.edu/neurology_facpub/38