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Abstract
INTRODUCTION: Vascular contributions to cognitive impairment and dementia (VCID) represent a major factor in cognitive decline in older adults. The present study examined the relationship between cerebrovascular reactivity (CVR) measured by magnetic resonance imaging (MRI) and cognitive function in a multi-site study, using a predefined hypothesis.
METHODS: We conducted the study in a total of three analysis sites and 263 subjects. Each site performed an identical CVR MRI procedure using 5% carbon dioxide inhalation. A global cognitive measure of Montreal Cognitive Assessment (MoCA) and an executive function measure of item response theory (IRT) score were used as outcomes.
RESULTS: CVR and MoCA were positively associated, and this relationship was reproduced at all analysis sites. CVR was found to be positively associated with executive function.
DISCUSSION: The predefined hypothesis on the association between CVR and a global cognitive score was validated in three independent analysis sites, providing support for CVR as a biomarker in VCID.
Document Type
Article
Publication Date
8-2024
Digital Object Identifier (DOI)
https://doi.org/10.1002/alz.13888
Funding Information
NIH, Grant/Award Numbers: UH3 NS100588, UH3 NS100606, UH3 NS100605, UH3 NS100614, U24 NS100591, R01 NS115771, P41 EB031771
Repository Citation
Liu, Peiying; Lin, Zixuan; Hazel, Kaisha; Pottanat, George; Xu, Cuimei; Jiang, Dengrong; Pillai, Jay J.; Lucke, Emma; Bauer, Christopher E.; Gold, Brian T.; Greenburg, Steven M.; Helmer, Karl G.; Jann, Kay; Jicha, Gregory; Kramer, Joel; Maillard, Pauline; Mulavelil, Rachel M.; Rodriguez, Pavel; Satizabal, Claudia L.; Schwab, Kristin; Seshadri, Sudha; Singh, Herpreet; Velarde Dediós, Ángel G.; Wang, Danny J. J.; Kalyani, Rita R.; Moghekar, Abhay; Rosenberg, Paul B.; Yasar, Sevil; Albert, Marilyn; and Lu, Hanzhang, "Cerebrovascular reactivity MRI as a biomarker for cerebral small vessel disease–related cognitive decline: Multi-site validation in the MarkVCID Consortium" (2024). Neurology Faculty Publications. 126.
https://uknowledge.uky.edu/neurology_facpub/126
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Developmental Neuroscience Commons, Epidemiology Commons, Geriatrics Commons, Health Policy Commons, Molecular and Cellular Neuroscience Commons, Neurology Commons, Psychiatry and Psychology Commons
Notes/Citation Information
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. © 2024 The Author(s). Alzheimer’s & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer’s Association.