Alzheimer’s disease and inflammatory biomarkers positively correlate in plasma in the UK-ADRC cohort
Abstract
INTRODUCTION: Protein-based plasma assays provide hope for improving accessibility and specificity of molecular diagnostics to diagnose dementia. METHODS: Plasma was obtained from participants (N = 837) in our community-based University of Kentucky Alzheimer’s Disease Research Center cohort. We evaluated six Alzheimer’s disease (AD)- and neurodegeneration-related (Aβ40, Aβ42, Aβ42/40, p- tau181, total tau, and NfLight) and five inflammatory biomarkers (TNF𝛼, IL6, IL8, IL10, and GFAP) using the SIMOA-based protein assay platform. Statistics were performed to assess correlations. RESULTS: Our large cohort reflects previous plasma biomarker findings. Relationships between biomarkers to understand AD–inflammatory biomarker correlations showed significant associations between AD and inflammatory biomarkers suggesting periph- eral inflammatory interactions with increasing AD pathology. Biomarker associations parsed out by clinical diagnosis (normal, MCI, and dementia) reveal changes in strength of the correlations across the cognitive continuum. DISCUSSION: Unique AD–inflammatory biomarker correlations in a community- based cohort reveal a new avenue for utilizing plasma-based biomarkers in the assessment of AD and related dementias.
Document Type
Article
Publication Date
2-2024
Digital Object Identifier (DOI)
https://doi.org/10.1002/alz.13485
Funding Information
Funding for this work was provided by National Institutes of Health (NIH) grants P30AG072946 (DMW, GAJ, PTN) and NIH Training Grant T32AG078110 (KEF).
Repository Citation
Foley, Kate E.; Winder, Zachary; Sudduth, Tiffany L.; Martin, Barbara J.; Nelson, Peter T.; Jicha, Gregory; Harp, Jordan P.; Weekman, Erica M.; and Wilcock, Donna M., "Alzheimer’s disease and inflammatory biomarkers positively correlate in plasma in the UK-ADRC cohort" (2024). Neurology Faculty Publications. 107.
https://uknowledge.uky.edu/neurology_facpub/107
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Notes/Citation Information
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. © 2023 The Authors. Alzheimer’s & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer’s Association.