Abstract

Introduction: We evaluated the relationship between baseline enlarged perivascular space (ePVS) burden and later cognitive decline.

Methods: 83 community-dwelling, older adults (aged 56–86) completed three annual cognitive assessments that included the Clinical Dementia Rating (CDR®) Dementia Staging Instrument Sum of Boxes (CDR-SB) and composite measures of executive function and episodic memory. An MRI scan at baseline was used to count ePVS in the basal ganglia and centrum semiovale. Mixed effects models were run with ePVS as the predictor variable and cognitive measures as the dependent variable. Covariates included age, sex, education, cerebral small vessel disease (cSVD) risk factors, and cSVD neuroimaging biomarkers.

Results: At baseline, high basal ganglia ePVS counts were associated with lower executive function scores and episodic memory scores. Moreover, baseline basal ganglia ePVS predicted worse longitudinal CDR-SB scores over the study period.

Discussion: Basal ganglia ePVS burden is a promising biomarker for cSVD-related cognitive and functional decline.

Document Type

Article

Publication Date

11-2024

Notes/Citation Information

0022-510X/© 2024 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by- nc/4.0/).

Digital Object Identifier (DOI)

https://doi.org/10.1016/j.jns.2024.123232

Funding Information

This work was supported by the National Institutes of Health [grant numbers NIA P30 AG072946 (Core F; Brian T. Gold), NIA P30 AG028383 - 15S1 (Brian T. Gold), NIA R01 AG055449 (Brian T. Gold), NIA R01 AG068055 (Brian T. Gold), NINDS RF1 NS122028 (Brian T. Gold), NIA F30 AG079506-01A1 (T.J. Libecap)]. The content is solely the responsibility of the authors and does not necessarily represent the official views of these granting agencies.

Download

Included in

Neurology Commons

Share

COinS