Year of Publication

2021

Degree Name

Master of Science (MS)

Document Type

Master's Thesis

College

Medicine

Department/School/Program

Medical Sciences

First Advisor

Dr. Jessica Blackburn

Abstract

Vascular endothelial growth factor (VEGF) is a signaling protein involved in inducing and regulating endothelial cell proliferation and function (Duffy et al 2000). VEGF is also involved in cancer progression, as it induces vascular permeability and promotes angiogenesis to tumor laden areas, giving cancer cells critical oxygen and nutrients (Hoeppner et al.,2012. Studies indicate VEGF prevents lymphoblast apoptosis, which may contribute to leukemia formation and enable the proliferation of leukemic cells (Duffy et al 2000). Ongoing research seeks to further examine VEGF in leukemia, using a rag2:GFP-Myc expressing transgenic zebrafish as the animal model of T-cell Acute Lymphoblastic Leukemia (T-ALL). Recent findings have concluded a relationship between VEGF expression in leukemic fish remodels the microenvironment leading to cell migration, but not through vascular restructuring, as a means to upregulate leukemic expression.

Digital Object Identifier (DOI)

https://doi.org/10.13023/etd.2021.093

Funding Information

This research was funded by the National Institutes of Health Director’s Fund, grant number DP2CA22804, between 9/1/17 to 5/30/22.

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